Evaluate the Efficacy of Xuebijing Injection in Acute Exacerbations of COPD

Inclusion Criteria: 1. Body weight≥40kg and ≤100kg 2. Diagnosis of COPD :(following Global initiative for Chronic Obstructive Lung Disease，GOLD2016) 3. Forced Expiratory Volume in 1 second of less than 70% predicted value after bronchodilator 4. Acute exacerbation of COPD: the clinical presentation of the patient complaining of an acute change of symptoms(baseline dyspnea,cough,and/or sputum production)that is beyond normal day-to-day variation. 5. Assessment of COPD Exacerbations: Medical History:severity of COPD based on degree of airflow limitation;Duration of worsening or new symptoms;Number of previous episodes (total/hospitalizations); Comorbidities; Present treatment regimen;Previous use of mechanical ventilation; 6. sign the informed consent Exclusion Criteria: 1. Pregnant women, lactating women； 2. Be allergic to Xuebijing； 3. Acute exacerbation of COPD onset of more than 72 hours； 4. AECOPD with severe hypoxemia：oxygenation index \<150 or received Endotracheal intubation invasive mechanical ventilation； 5. Participation in another experimental protocol within 30 days of study entry 6. Primary diseases：Asthma，Cystic fibrosis，Lung cancer，Tuberculosis，Pulmonary sarcoidosis，Pulmonary interstitial fibrosis，Malignant neoplasms，Blood system diseases，HIV； 7. Complications：Pulmonary embolism，shock，DIC，Unstable cardiovascular disease，Upper gastrointestinal bleeding，pneumothorax，Severe liver and kidney dysfunction； 8. Mental incompetence or active psychiatric illness 9. used the following drugs within 72 hours days of study entry：Ulinastatin，Tanreqing， Reduning，Qingkailing； 10. The investigator judged that the subject could not be completed or should not participate in the trial：Hemodialysis more than 1 mouth，Organ transplant patients with potential medical dispute.