Endoscopic Ultrasound-guided Needle-based Confocal Laser Endomicroscopy for Evaluation of Malignant Lymph Nodes - a Pilot Study

Shandong University30 enrolled

Overview

Current modalities for lymph node staging in cancer can be limited. Needle-based confocal laser endomicroscopy (nCLE) is a novel endoscopic technique, which is compatible with the 19-gauge FNA needle. Under endoscopic ultrasonography (EUS) guidance, nCLE enables real-time in vivo imaging of lesion tissues at cellular and subcellular levels.This study aimed to evaluate the feasibility of needle-based confocal laser endomicroscopy (nCLE) at the time of endoscopic ultrasound (EUS) and to describe the nCLE features that distinguish between benign and malignant lymph nodes.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Malignancy or Benign of Enlarged Lymph Nodes

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing EUS for staging of malignancy or assessment of enlarged lymph nodes Exclusion Criteria: * Patients aged \<18 years or \>80 years * Known allergy to fluorescein dye * Previous EUS-FNA performed within the past 3 months, and usualcontraindications to EUS-FNA * Pregnancy or breastfeeding * Inability to provide informed consent

Locations (1)

Department of Gastroenterology, Qilu Hospital, Shandong University

Endoscopic Ultrasound-guided Needle-based Confocal Laser Endomicroscopy for Evaluation of Malignant Lymph Nodes - a Pilot Study

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts