Sugammadex Reversal of Neuromuscular Blockade and Postoperative Bleeding

Mansoura University40 enrolled

Overview

Sugammadex is new drug that is used for reversal of rocuronium induced muscle relaxation. benefits of reversal of neuromuscular blockade appears to be of great value in living donor liver transplant recipients. However, Few Clinical reports have investigated the anticoagulant effect of sugammadex. In this study, effects of sugammadex on bleeding profile of living donor liver transplantation will be investigated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

DOUBLE

Enrollment

Conditions

Blood Coagulation Tests ( INR, APTT)

Interventions

Sugammadex intravenousDRUG

Intravenous Injection of sugammadex (2 mg/kg) for reversal of rocuronium induced muscle relaxation

Intravenous neostigmine and atropineDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * all candidates for living donor liver transplantation Exclusion Criteria: * massive intraoperative bleeding manifestations of early graft dysfunction

Locations (2)

Mansoura university

Al Mansurah, Dkahleya, Egypt

RECRUITING

Gastroenterology center

Al Mansurah, Egypt

RECRUITING

Outcomes

Primary Outcomes

activated partial thromboplastin tile in seconds

Time frame: 30 min

Secondary Outcomes

international normalized ratio in second

Time frame: 30 min

Data from ClinicalTrials.gov

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