Should Colon or Non-colon Originated Lesions be Distinguished?

Inclusion Criteria: 1. Patients in our ICU aged 18-75 years. 2. Patients with a confirmed diagnosis of ALGID. Exclusion Criteria: 1. mechanical intestinal obstruction (including tumor, stercoral obstruction etc.) 2. gastrointestinal hemorrhage within 72 hours. 3. history of inflammatory bowel disease (ulcerative colitis or Crohn's disease) or radiation enteritis. 4. pregnancy. 5. contraindications of neostigmine administration.