NIV Application in the Treatment of Asthmatic Children

University of Nove de Julho68 enrolled

Overview

Asthma is characterized by recurrent episodes of bronchospasm, bronchial hyperresponsiveness and chronic airway inflammation and pharmacological treatment for this condition is done with bronchodilators and anti-inflammatory.

Pharmacologic therapy has clinical efficacy in the control, but the patient often does not adhere adequately. There is need for further research into non-pharmacological therapies for clinical asthma control and in turn the use of CPAP and bilevel pressure in the airways has shown beneficial effects on autonomic modulation and bronchial responsiveness leading to the hypothesis that these therapies also have effects on the BIE.The aim of this study is to evaluate the effect of these non-pharmacological therapies in several variables and especially the BIE.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Asthma Child Bronchial Spasm

Interventions

muscle trainingDEVICE

Continue Positive Airway PressureDEVICE

bilevel positive airway pressureDEVICE

Eligibility

Sex: ALLMin age: 5 YearsMax age: 11 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 5:11 years; * Both sexes; * Do not be included in any regular physical activity program; * Having a diagnosis of asthma, according to the Global Initiative for Asthma (GINA); * Not having received Theophylline or aminophylline and oral corticosteroids in the last 30 days; * not have presented respiratory infection in the last two months; * Signature of IC Exclusion Criteria: * Have done inhaled bronchodilator in less than 12 hours before the assessment; * Inability to understand or perform any of the tests, due to physical and mental limitations; * Intolerance proposed activities; * Have heart disease inflammatory, congenital or ischemic origin; * Being in the presence of any infectious process with fever.

Locations (1)

Maisi David Cabral

São Paulo, Brazil

Outcomes

Primary Outcomes

Exhaled nitric oxide (part per billion)

assess the degree of inflammation of the respiratory system using expired fraction of nitric oxide before and after the different protocols applied

Time frame: 5 minutes

Secondary Outcomes

Heart Rate Variability

Time frame: 20 minutes

manovacuometry

Time frame: 10 minutes

Pulmonary function test

Time frame: 20 minutes

bioelectrical impedance

Time frame: 10 minutes

Bronchoconstriction induced by stress

Time frame: 30 minutes

Data from ClinicalTrials.gov

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