Various Serving Sizes of Lentils on Blood Glucose and Insulin

University of Guelph48 enrolled

Overview

The purpose of this study is to assess the effects of consuming either 1/2 or 1/4 cup servings of lentils on post-prandial blood glucose and insulin as compared to 4 types of starchy foods (corn, macaroni, white potato, white rice).

Eligible participants will undergo a total of 6 study visits. During each visit, a fasted blood sample will be taken by fingerprick, and approximately 500 µL of blood will be dripped into a collection tube. The participant will then consume a meal of either: two types of lentils, corn, macaroni, white rice, or white potato. All study days will be randomized. Each meal will be served in either 1/4 or 1/2 cup servings depending on the study block. Six more blood samples will be taken by fingerprick at 15, 30, 45, 60, 90 and 120 minutes after the beginning of the meal.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

1/4 cup- Small red lentilOTHER

1/4 cup- Small green lentilOTHER

1/4 cup- cornOTHER

1/4 cup- macaroniOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria * Healthy men and women * Age 18-40 years * Body mass index (BMI) 20-30 kg/m2 Exclusion Criteria: * Tobacco use * Pregnant or breastfeeding * Fasting blood glucose ≥ 7.0 mmol/L * Two hour blood glucose ≥ 11.1 mmol/L after consuming 75g glucose drink (Oral Glucose Tolerance Test beverage) * Any major medical condition including a history of AIDS or hepatitis * Medical or surgical event requiring hospitalization within 3 months of randomization * Any medications except a stable dose (3 months) of oral contraceptives, blood pressure or statin medications * Blood pressure \>140/90 mm Hg * Natural health products (NHPs) used for glycemic control * Probiotic supplements * Dietary fibre supplements * Consumption of \>4 servings of pulses per week * Food allergy or non-food life threatening allergy * Shift workers * Alcohol consumption \>14 drinks/week or \>4 drinks/sitting * Recent or intended significant weight loss or gain (\>4 kg in previous 3 months) * Elite athletes

Locations (1)

Human Nutraceutical Research Unit

Guelph, Ontario, Canada

Outcomes

Primary Outcomes

Postprandial Blood Glucose

Time frame: 2 hours Postprandial

Postprandial Blood Insulin

Time frame: 2 hours postprandial

Data from ClinicalTrials.gov

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