Timing of Surgery And Outcome in Burn Patients ( EARLYBURN )

Assistance Publique - Hôpitaux de Paris470 enrolled

Overview

The prognostic of burn patients has improved over the last decades. Early excision of full thickness burns is thought to be one of the key factors which have led to prognostic improvement. Best timing for burn excision remain uncertain, however. In this multicenter observational study, we aim at exploring the impact of timing of surgery on outcome in severely ill burn patients using a propensity analysis.

The first aim of the study is to explore the impact of timing of the first surgery on outcome of severely ill burn patients. Because a randomization would not be feasible in this setting, we will use a propensity analysis in matching patients receiving early surgery and those receiving late surgery. Secondary aims are to evaluate the impact of the timing of surgery on morbidity (organs failure, infections, sepsis) but also to assess the diagnostic and prognostic value of plasma and urine biomarkers in severely ill burn patients

Study Type

OBSERVATIONAL

Enrollment

470

Conditions

Burns

Interventions

Early Excision of full thickness burnPROCEDURE

first excision surgery of full -thickness burn performed within 48 hours from burn injury

Late Excision of full thickness burnPROCEDURE

first excision surgery of full -thickness burn performed after 48 hours from burn injury

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \>18 years * Admission to a burn unit within 72 hours from a burn injury * Total burned surface area (TBSA)\>20%(2nd degree or 3rd degree) for any type of burn * Patient covered by the social security * Non-opposition to participate to the study and to the constitution of the biological collection Exclusion Criteria: * Decline to participate * Decision not to resuscitate order before surgery * Pregnant or breastfeeding patiente * Decision to limit therapies in the first 24 hours * Patient not resident in France * Patient deprived of liberty

Locations (1)

Departement of Anesthesiology, Critical Care and Burn Unit; Saint-Louis hospital, University Paris Diderot

Paris, France

Outcomes

Primary Outcomes

mortality

Time frame: 90 days

Secondary Outcomes

Organ failure

Time frame: 28 and 60 days

Recovery from acute kidney

Time frame: Until 28 and 60 days from burn injury

Median Sequential Organ Failure Assessment score (SOFA score) during first 28 days

Median Sequential Organ Failure Assessment score (SOFA score) during first 28

Time frame: First 28 days

Nosocomial infections (numbers) during first 60 days

Time frame: First 60 days

Nosocomial sepsis during first 60 days

Time frame: First 60 days

Length of stay in the ICU

Time frame: One year

analog scale of quality of life

Functional sequel at one year, the patient will assesassess his overall quality of life since his accident Scale 1 to 10, with 1: poor, 10: good

Time frame: One year

One year mortality

Time frame: One year

Data from ClinicalTrials.gov

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