Thromboembolism is an important perioperative complication in major thoracic surgery, even though current guidelines have recommended postoperative administration of heparin or LMWH for thromboprophylaxis for those high-risk patients, there are still many cases of thromboembolism. Therefore, as the guideline itself writes, the investigators believe the rational of dose and timing of heparin in thoracic surgery are still not well established. Therefore, the investigators aimed to conduct this randomized controlled study to explore the safety and efficacy of preoperative Administration of Heparin as Thromboprophylaxis in Major Thoracic Surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
2,000
Department of thoracic surgery, west china hospital, sichuan university
Chengdu, Sichuan, China
RECRUITINGintraoperative bleeding volume (ml)
During the operation, the blood loss of each patient was collected and measured, and recorded by the investigators.
Time frame: the bleeding volume (ml) during operation in the operation room for all patients
chest tube drainage volume (ml)
Time frame: from postoperative day 1 to chest tube remove(usually on postoperative day 3 for lobectomy or thymectomy,on postoperative day 7 for esophagectomy )
thromboembolism occurence rate (%)
Time frame: within 30 days after surgery
APTT (s)
Time frame: on postoperative day 1 for both group
PT(s)
Time frame: on postoperative day 1 for both group
INR
Time frame: on postoperative day 1 for both group
blood platlet count(/L)
Time frame: on postoperative day 1 for both group
chest tube drainage duration (days)
Time frame: from postoperative day 1 to chest tube remove(usually on postoperative day 3 for lobectomy or thymectomy,on postoperative day 7 for esophagectomy )
PT(s)
Time frame: rightly upon hospital admission day
APTT(s)
Time frame: rightly upon hospital admission day
INR
Time frame: rightly upon hospital admission day
blood platlet count(/L)
Time frame: rightly upon hospital admission day
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