SBRT in Multi-metastatic NSCLC Patients Which Are Pan-negative for Driver Mutations

Inclusion Criteria: * Histologically proven non-small-cell lung cancer. * Stage IV according to UICC stage system(version 7,2009).The number of metastatic lesions\>5 * Pan-negative for driver mutations including EGFR ALK ROS1 c-MET * At least Three evaluable lesions among which at least two must be suitable for SBRT. * ECOG performance status 0-2. * Expected lifespan ≥3 months. * No brain metastasis in MRI. * No liver metastasis in abdominal CT or MRI. * No malignant pleural effusion or pericardial effusion from chest CT and/or pathology. * Stable lab values: Hematological: Absolute neutrophil count (ANC) ≥1.5×109/L, Platelets ≥100×109/L, Hemoglobin ≥9 g/dL Renal: Creatinine OR Measured or calculated creatinine clearance (CrCl) (glomerular filtration rate \[GFR\] can also be used in place of creatinine or CrCl) ≤1.5× the upper limit of normal (ULN) OR ≥60 mL/min for patient with creatinine levels \>1.5× institutional ULN Hepatic: Total bilirubin ≤1.5×ULN OR Direct bilirubin ≤ULN for patients with total bilirubin levels \>1.5×ULN, Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5×ULN OR ≤5×ULN for patients with liver metastases ,globulin≥20 g/L, albumin≥30 g/L. \- Able to understand and give written informed consent and comply with study procedures. Exclusion Criteria: * Any unstable systemic disease, including active infection, uncontrolled high blood pressure, unstable angina, newly observed angina pectoris within the past 3 months, congestive heart failure (New York heart association (NYHA) class II or higher), myocardial infarction onset six months before included into the group, and severe arrhythmia, liver, kidney, or metabolic disease in need of drug therapy. * Previously diagnosed with immunodeficiency disease. * Human immunodeficiency virus (HIV) infection. * Women in pregnancy or lactation . * Patients with mental illness, considered as "can't fully understand the issues of this research". * other Cancer history. * Histologically confirmed small cell carcinoma or other non NSCLC compositions in the cancer tissue. * Brain metastasis or liver metastasis or malignant pleural effusion or pericardial effusion. * Allergy of rhGM-CSF and its accessories. * Contraindications to GM-CSF treatment.