Exploration of Cerebral Pathophysiology During and After CABG Using CPB

Rigshospitalet, Denmark24 enrolled

Overview

Purpose: The purpose of this study is to examine cerebral oxidative and inflammatory stress and cerebral hemodynamics during and after coronary artery bypass grafting and correlate with postoperative cognitive function.

Postoperative cognitive decline is a well-known and well-described complication following coronary artery bypass grafting. Severity ranges from postoperative delirium to stroke, but the majority of patients with postoperative cognitive decline following coronary artery bypass grafting have decline in recent and remote memory in particular. The reason for the cognitive decline is still not fully understood though many reasons have been proposed. Inflammation and oxidative stress may contribute to the postoperative cognitive dysfunction which may also be in combination with a reduced cerebral autoregulation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Ischemic Heart Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with ischemic heart disease admitted for coronary artery bypass grafting with the use of cardiopulmonary bypass Exclusion Criteria: * Cerebrovascular disease

Outcomes

Primary Outcomes

Cerebral autoregulation

Flow measurement of middle cerebral artery and measurement of middel arterial pressure

Time frame: 6 hours post operation

Secondary Outcomes

Postoperative cognitive function

Time frame: One day prior to operation and three days after operation

Data from ClinicalTrials.gov

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