Piezoelectric Vibrations and Tissue, Cellular and Molecular Mechanisms of Oral Wound Healing After Third Molar Surgery

University of Belgrade40 enrolled

Overview

The aim of this clinical trial is to investigate and compare the effect of piezoelectric surgery on tissue, cellular and molecular level of oral surgical wound healing and postoperative outcomes (pain, swelling, trismus) after lower third molar surgery in healthy patients

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Tooth, Impacted

Interventions

piezo surgeryPROCEDURE

conventional surgeryPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * bilaterally symmetrically impacted lower third molars Exclusion Criteria: * presence of intraoral infection * chronic orofacial pain * pregnancy/ lactation * heavy tobacco smokers * alcohol/ drug abuse * allergic reaction to medicaments used

Locations (1)

School of Dental Medicine, University of Belgrade

Belgrade, Serbia

Outcomes

Primary Outcomes

SOD activity in alveolar bone specimen

Activity of enzyme superoxide dismutase in bone specimens obtained during lower third molar surgery

Time frame: immediately after surgery

VEGF levels in alveolar bone specimen

Time frame: immediately after surgery

MMP-9 level in alveolar bone specimen

Time frame: immediately after surgery

Data from ClinicalTrials.gov

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