Multidisciplinary Intervention for Mild Cognitive Impairment

Gibson Institute of Cognitive Research5 enrolled

Overview

The purpose of this investigation is to conduct a series of case studies on the impact of a novel functional medicine approach to improving cognitive skills, brain structure, and daily functioning for participants with Mild Cognitive Impairment (MCI).

Using a multiple baseline design across cases with start point randomization, the proposed study will examine the outcomes from a combination of optimized diet, exercise, nutritional supplements, and cognitive training across domains on standardized measures used to monitor treatment effectiveness for Mild Cognitive Impairment (MCI).

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Mild Cognitive Impairment

Interventions

Cognitive trainingBEHAVIORAL

A clinician will deliver three 90-minute cognitive training sessions per week for 14 weeks. There are 16 different categories of leveled training procedures sequenced in intensity and difficulty for a total of 530 training tasks.

NutritionDIETARY_SUPPLEMENT

Participants will be given dietary recommendations and nutritional supplements to optimize cognition.

Eligibility

Sex: ALLMin age: 50 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 50+ previously diagnosed with MCI * Living in the greater Colorado Springs area Exclusion Criteria: * No braces, metal implants, or claustrophobia that would contraindicate magnetic resonance imaging

Locations (1)

Gibson Institute of Cognitive Research

Colorado Springs, Colorado, United States

Outcomes

Primary Outcomes

Evidence of overall cognitive function improvement

Confirmed by change in pretest to post-test scores on the Dementia Rating Scale (DRS-2)

Time frame: within 14 days after completing the intervention

Secondary Outcomes

Evidence of improvement in executive function

As confirmed by pretest to post-test changes on the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A)

Time frame: within 14 days after completing the intervention

Evidence of improvement in cognitive flexibility

As confirmed by pretest to post-test changes on a Trail Making Test

Time frame: within 14 days after completing the intervention

Evidence of change in brain function

Confirmed by change in pretest to post-test neuroimaging using MRI

Time frame: within 30 days after completing the intervention

Evidence of improvement in visual attention

Confirmed by change in pretest to post-test scores on the Conners Continous Performance Test (CPT-3)

Time frame: with 14 days after completing the intervention

Evidence of improvement in auditory attention

Confirmed by change in pretest to post-test scores on the Auditory Attention Test (CATA)

Time frame: with 14 days after completing the intervention

Data from ClinicalTrials.gov

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