The aim of this study is to investigate long-lasting or later behavioral changes in children in the context of different anesthesia techniques (Inhalation anesthesia vs. TIVA)
The process of surgery and anaesthesia can be an extremely frightening and stressful event for a child, and is frequently followed by negative postoperative behavioural changes. This Event could be associated with poor postoperative outcome and long term behavior problems like anxiety, eating or sleeping disorders. The aim of this study is to investigate long-lasting or later behavioral changes in children in the context of different anesthesia techniques (Inhalation anesthesia vs. TIVA). After anesthesia initiation, anesthesia maintenance should be done with sevoflurane or Tiva. The effect of behavioral changes in children in the context of anesthesia techniques should be evaluate by post hospitalisation behavior and Strengths and Difficulties Questionnaire at first, second and fourth week. Early postoperative problems like postoperative nausea and vomiting, pain level, pain therapy and postoperative awareness should be evaluate too.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SCREENING
Masking
QUADRUPLE
Enrollment
500
TIVA is use to anesthesia maintenance after anesthesia induction (Propofol 10mg/kg/h, Remifentanil 0.2mcg/kg/min, dose adaptation as required for sufficient anesthesia)
Sevoflurane is use to anesthesia maintenance after anesthesia induction (target et 2 Vol% in 50-70% N2O, dose adaptation as required)
Dr. Philipp Buehler
Zurich, Switzerland
Post-Hospital Behaviour Questionnaire (PHBQ) score postoperatively
child's PHBQ score first week postoperatively
Time frame: first week postoperative
Post-Hospital Behaviour Questionnaire (PHBQ) score postoperatively
child's PHBQ score second week postoperatively
Time frame: second week postoperative
Post-Hospital Behaviour Questionnaire (PHBQ) score postoperatively
child's PHBQ score fourth week postoperatively
Time frame: fourth week postoperative
SDQ Questionnaire score postoperatively
child's SDQ score first week postoperatively
Time frame: first week postoperative
SDQ Questionnaire score postoperatively
child's SDQ score second week postoperatively
Time frame: second week postoperative
SDQ Questionnaire score postoperatively
child's SDQ score fourth week postoperatively
Time frame: fourth week postoperative
postoperative pain Level (by VAS)
Visual Analog Scale for Pain (VAS Pain) were used to evaluate postoperative pain level
Time frame: in the first postoperative week (3 times a day)
postoperative pain Level (by CHEOPS)
CHEOPS (Children's Hospital of Eastern Ontario Pain Scale) were used to evaluate postoperative pain level
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Time frame: in the first postoperative week (3 times a day)
postoperative pain medication
All pain medications are recorded during the first postoperative week.Nurses and parents recorded all substance and application times by questionnaire.
Time frame: in the first postoperative week
Intraoperative awareness
In order to record an intraoperative awareness, a semistructured interview is conducted with test questions.
Time frame: in the first and second postoperative day
postoperative Nausea and vomiting
Nausea and Vomiting are recognized in frequency and time using a questionnaire.
Time frame: in the first and second postoperative day