Treatment of Peri-calcification Edema in Neurocysticercosis (NCC)

Phase 3TerminatedNCT02945527

Universidad Peruana Cayetano Heredia4 enrolled

Overview

Three-arm open, randomized comparative study of acetazolamide, dexamethasone, or no additional treatment to evaluate decrease in peri-calcification edema in neurocysticercosis

This study will evaluate 24 patients with calcified NCC and edema in three treatment arms to compare the reduction in edema volume

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Neurocysticercosis

Interventions

AcetazolamideDRUG

As described above

DexamethasoneDRUG

As described above

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Calcified NCC * Perilesional edema on CT or MRI * Normal lab values Exclusion Criteria: * Viable neurocysticercosis * Status epilepticus * Symptomatic intracranial hypertension * Tuberculosis * More than 7 days after seizure * Pregnancy

Locations (1)

Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas

Lima, Peru

Outcomes

Primary Outcomes

Decrease in Volume of Perilesional Edema Between Baseline and Day 4

MRI extension of edema

Time frame: Baseline to Day 4

Secondary Outcomes

Decrease in Volume of Perilesional Edema Between Baseline and Day 8

MRI extension of edema

Time frame: Baseline to Day 8

Decrease in Volume of Perilesional Edema Between Baseline and Day 30

MRI extension of edema

Time frame: Baseline to Day 30

Data from ClinicalTrials.gov

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