Predictive Factors of Acute Oral Mucositis Induced by Chemo-radiotherapy for Local Advanced Nasopharyngeal Carcinoma

Inclusion Criteria: 1. Histologically conformed Initial nasopharyngeal carcinoma 2. Patients can feed through the mouth. 3. ECOG (Eastern Cooperative Oncology Group) : 0-1. 4. No history of chemo-radiotherapy, immuno-therapy or biotherapy. 5. Normal hemodynamic indices before the recruitment (including white blood cell count\>4.0×109/L, neutrophil count\>1.5×109/L, platelet count \>100×109/L, hemoglobin≥90g/l, normal liver/kidney function). 6. Informed consent signed. Exclusion Criteria: 1. History of malignant tumors. 2. Any severe complications contraindicated chemotherapy or radiotherapy. 3. Medical history of central nervous system, cognitive or psychological diseases; 4. Pregnant or nursing women. 5. Patients with mental disease cannot complete the questionaire. 6. Patients refused the informed consent.