Treatment of Moderate and Severe Cirrhotic Portal Hypertension Due to HBV With Fuzheng Huayu and Entecavir

Inclusion Criteria: * More than 6 months history of serum positive HBsAg * Abdominal ultrasonogram or CT scan or liver-biopsy specimen indicates liver cirrhosis * Age 18-65 * Child-Pugh\<7 (Stage A) * Without portal hypertension（Endoscopy indicates no signs of gastroesophageal varices.） * Moderate and Severe of portal hypertension（Endoscopy indicates signs of gastroesophageal varices that is line shape without red wales or spots and less than 0.3cm of diameter.） * The patient or the patient's guardian agrees to participate the random controlled trial and sign the Informed Consent Form. Exclusion Criteria: * Primary Lamivudine, Adefovir dipivoxil and Entecavir resistance * Decompensated cirrhosis、The Child-Pugh score≥7 * Low-grade Cirrhotic Portal Hypertension. * Severe grade of portal hypertension（Endoscopy indicates signs of gastroesophageal varices that is catenulate/nodular shape with or without red wales or spots and more than 1.0cm of diameter.） * Decompensated liver cirrhosis Liver cancer * Liver histology conforming to other chronic liver diseases, such as moderate or severe non-alcoholic fatty liver disease(more than 1/3 steatosis in liver ), chronic hepatitis C, chronic hepatitis D, autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, inherited metabolic liver disease, drug or toxic induced liver injury, parasitic infections, alcoholic liver disease. * Have psychiatric history or uncontrollable epilepsy patient. * Uncontrollable diabetic patient * History of hemoglobin disease (such as alpha- or beta-thalassemia, sickle cell disease, spherocytosis) or patients with toxic or autoimmune hemolytic anemia. * Severe background disease like chronic respiratory failure, circulatory failure, kidney failure etc. * In situ organ transplantation (such as liver, kidney, lung and heart) or bone marrow transplantation and stem cell transplantation. * Immunocompromised patients: such as HIV infection or take immunosuppressor or glucocorticoid (such as cyclosporin, azathioprine, adrenocortical hormone) within 3 months or chemotherapy drugs (such as cyclophosphamide, ammonia and cancer chemotherapy) and radioactive therapy. * Gestation or lactation period women and women who plan to get pregnant during the study period. * Patient who are allergy to the experimental drug. * Using history of anti-viral or anti-fibrosis drug within 6 months. * Patients who are participating other trials. * Other situation where PI thinks the patient should be excluded.