Prognostic Impact of Noncardiac Comorbidities in Heart Failure Patients

Ospedale Maggiore Di Trieste2,314 enrolled

Overview

To better understand the public health prognostic impact of noncardiac chronic illnesses, we explored the attributable risk of noncardiac comorbidities on outcomes between heart failure patients with reduced ejection fraction (HFREF) and heart failure patients with preserved ejection fraction (HFpEF) in a large contemporary heart failure (HF) population The adjusted hazard ratio (HR) and the population attributable risk were used to compare the contributions of 15 noncardiac comorbidities to adverse outcome. The comorbidities that contributed to high attributable risk were: anemia, chronic kidney disease, chronic obstructive pulmonary disease, diabetes mellitus, and peripheral artery disease. These findings were similar for HFrEF and HFpEF groups. Interaction analysis confirmed similar results.

Study Type

OBSERVATIONAL

Enrollment

2,314

Conditions

Heart Failure, Diastolic Heart Failure, Systolic

Interventions

prognostic impact of non cardiac comorbidities

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All consecutive heart failure patients with left ventricular ejction fraction available before or within 3 months from the index visit Exclusion Criteria: * We excluded all patients who had severe primary left-sided valvular disease

Outcomes

Primary Outcomes

overall mortality

Time frame: 2 years

Secondary Outcomes

First all-cause hospitalization

Time frame: 2 years

Heart Failure hospitalization

Time frame: 2 years

noncardiovascular hospitalization

Time frame: 2 years