Facilitating the Behavioral Treatment of Cannabis Use Disorder

Inclusion Criteria: * Meets DSM-IV criteria for cannabis dependence, with at least 5 days of use per week over the past 30 days and displaying at least one positive utox during screening * Physically healthy * No adverse reactions to study medications * 21-60 years of age * Capacity to consent and comply with study procedures * Seeking treatment Exclusion Criteria: * Meets DSM IV criteria for current major depression, bipolar disorder, schizophrenia, any psychotic illness, including substance-induced psychosis, and current substance-induced mood disorder. * Physiological dependence on another substance requiring medical management, such as alcohol, opioids, or benzodiazepines, excluding caffeine, and nicotine. * Pregnant, interested in becoming pregnant, or lactating * Delirium, Dementia, Amnesia, Cognitive Disorders, or dissociative disorders * Current suicide risk or a history of suicide attempt within the past 2 years * On psychotropic or other medication whose effect could be disrupted by participation in the study * Recent history of significant violence (past 2 years). * Heart disease as indicated by history, abnormal ECG, previous cardiac surgery. * Unstable physical disorders which might make participation hazardous such as end-stage AIDS, hypertension (\>140/90), anemia, pulmonary disease, active hepatitis or other liver disease (transaminase levels \< 2-3 X the upper limit of normal will be considered acceptable), or untreated diabetes * Previous history of misuse of study medications * BMI \> 35, or a history of undocumented obstructive sleep apnea * First degree relative with a psychotic disorder (bipolar disorder with psychotic features, schizophrenia, schizoaffective disorder, or psychosis NOS)