S1 Plus Docetaxel Versus Capecitabine Plus Docetaxel First-line Treatment in Patients With Advanced Breast Cancer

Inclusion Criteria: * 18 ≤ age ≤ 75; * ECOG 0-2, The expected survival time more than 3 months; * Histologically or cytologically proven locally advanced or advanced HER-2 negative breast cancer; * No chemical treatment after Cancer recurrence; * At least one measurable disease ( as per RECIST1.1); * Adequate bone marrow functions (ANC ≥1.5×109 /L, PLT ≥100×109 /L, HB ≥90 g/L); * Adequate renal functions(serum creatinine ≤ 1.5 ULN; creatinine clearance≥50 ml/min); * liver functions (serum bilirubin ≤ 1.5ULN, AST/ALT ≤ 2.5 ULN); * Written informed consent; * Pregnancy test (serum or urine) within 7 days of entry and willing to use the appropriate method of contraception. Exclusion Criteria: * Previously chemotherapy with cytotoxic drugs * Pregnant, lactating women Did not take effective contraceptive measures * Adjuvant chemotherapy/ neoadjuvant chemotherapy with 5-FU-based chemotherapy or Paclitaxel -based chemotherapy within 1 year after recurrence; * Her-2 positive or unknown * Other trails Before 4weeks * Affection of the absorption of drugs(Unable to swallow、after gastrectomy、Chronic diarrhea and intestinal obstruction * Organs with rapid progression of invasion(Liver and lung lesions more than 1/2 organ area or hepatic insufficiency) * Central nervous system disorders or mental disorders * For docetaxel or fluorouracil or Twain 80 had serious adverse reactions or Allergy to 5-FU * Severe upper gastrointestinal ulcer or absorption dysfunction syndrome * Abnormal blood routine (ANC \<1.5×109 /L, PLT \<100×109 /L, HB \<90 g/L); * Renal functions(serum creatinine \> 1.5 ULN); * Liver functions (serum bilirubin \> 1.5ULN * Brain metastases out of control * Other unapplicable