Omega-3 Fatty Acids in Sickle Cell Disease

Inclusion Criteria: Subjects who meet all of the following criteria are eligible for enrollment into the study: * Participant has signed the informed consent/assent with parent signing informed consent as age appropriate. * Established diagnosis of HbSS, HbSC or HbSβo Thalassemia * History of ≥1 vasoocclusive events (managed at home and/or in hospital) in preceding 12 months. * Regular compliance with comprehensive care. * Aged 8 years or greater and less than 26 years. * At enrollment, subject should be in his/her baseline steady state and not in the midst of any acute complication due to SCD. Must be at least 2 weeks from infection or vasoocclusive crisis at time of screening labs Exclusion Criteria: * Baseline hemoglobin levels \<5.5 gm/dL. * Inability to swallow capsules * Poor compliance with previous treatment regimens. * Hepatic dysfunction * Renal dysfunction * PT and/or PTT ≥ 20% outside of normal * Allergy to fish, shell fish or soy * Triglyceride levels \<80mg/dL. * Pregnancy. * Chronic Transfusion Therapy. * Transfusion within the last 30 days. * Treatment with any investigational drug or regular fish oil supplementations in last 60 days. * Currently receiving another investigational agent, or on such an agent with the last 60 days. * Dosage changes in preceding 3 months if on hydroxyurea * Diagnosed bleeding disorder or patient on concomitant anti-coagulation. * Conditional or abnormal result on most recent transcranial doppler or history of stroke. * Other active chronic illness that could adversely affect subjects performance * Children in Care * Platelet count less than 100,000