Investigation of the Role of the Microbiome in the Pathogenesis of Colorectal Adenoma and Carcinoma

Lower GI endoscopy patients Inclusion Criteria: * Participant is willing and able to give informed consent for the participation in the study before any protocol-specific screening procedures are performed * Male or female, aged 18 years or above * Referred to lower GI endoscopy. Referral reasons can be among others: * Positive FOBT (Fecal Occult Blood Test) * Follow up after polypectomy * Screening because of age * Bleeding * Abdominal pain * Familial or past history of colon cancer or adenoma * Abnormal imaging such as barium enema * Change in bowel habits * Both self-referrals, referrals from external GP or specialists and internal referrals can be included. Exclusion Criteria: * Previous diagnosis of an inflammatory bowel disease * Previous diagnosis of intestinal polyposis syndrome CRC patients Inclusion criteria: * Participant is willing and able to give informed consent for the participation in the study before any protocol-specific screening procedures are performed * Male or female, aged 18 years or above * Diagnosis of CRC for which resection is planned * Both internal and external referrals from specialists can be included Exclusion Criteria: * Previous diagnosis of an inflammatory bowel disease * Previous diagnosis of intestinal polyposis syndrome