Polyneuropathy in Diabetes Mellitus Type 2

Danish Pain Research Center490 enrolled

Overview

This is a population-based study of type 2 diabetes patients with and without neuropathy recruited from the Danish National Type 2 Diabetes cohort (DD2). Perspective: The study will identify risk factors for developing diabetic polyneuropathy and painful diabetic polyneuropathy and provide information on the underlying mechanisms, which will hopefully contribute to significant improvements in the treatment and prevention of diabetic polyneuropathy in future.

Diabetic polyneuropathy is one of the most common long-term complications of diabetes. Neuronal hyperexcitability is thought to be a key factor in the development of neuropathic pain. The overall purpose of this study is to evaluate the prevalence and underlying mechanisms of diabetic polyneuropathy and painful diabetic polyneuropathy.

Study Type

OBSERVATIONAL

Enrollment

490

Conditions

Diabetes Mellitus Type 2 Without Complication Polyneuropathies, Diabetic Diabetes Complications Diabetic Peripheral Neuropathy Chronic Pain

Medical Language ↔ Plain English

Inclusion Criteria T2D patients: * Clinical diagnosis of type 2 diabetes Exclusion Criteria: * Pregnancy * Poor or no Danish language skills * Insufficient mental capacity to provide informed consent or complete questionnaires Additional criteria for healthy controls: * Any neurological or psychiatric disorder * Chronic pain * Severe illness * Pain treatment 3 days before the examination

Locations (2)

Danish Pain Research Center, Aarhus University Hospital

Aarhus, Denmark

Odense University Hospital

Odense, Denmark

Outcomes

Primary Outcomes

Presence of diabetic polyneuropathy

For case definition of neuropathy, Tesfaye et al. 2010 will be used.

Time frame: 5 hours

Presence of painful diabetic polyneuropathy

Neuropathic pain grading system. Finnerup et al. 2016 will be used.