Using Preimplantation Genetic Diagnosis in Autosomal Dominant Polycystic Kidney Disease Patients: a Multicenter Clinical Trial

Inclusion Criteria: * Only one ADPKD patient in one couple without gender limitation * Wife has age limitation from 20 years to 35 years * ADPKD ADPKD diagnosis with or without family history * Find out specific pathogenic mutations in the PKD1 gene with at least one of the following: one of family patients done kidney transplantation or renal replacement therapy before 58 years old; one of family patients died of complications before 55 years old; the patient with total kidney volume more than 650ml; the patient with total kidney volume increase rate more than 6% every year; the patient's PKD1 mutation belongs to truncated gene mutation. * Both husband and wife have assisted reproductive conditions and will * Pregnancy compliance with Chinese laws * Signed informed consent Exclusion Criteria: * Active pathogenic microorganism infection, such as hepatitis B or C, HIV, pulmonary tuberculosis, giant cell virus, fungi or other contraindications for preimplantation genetic diagnosis and so on * Any one of the couple has used any drugs which may lead to abnormal reproductive system function, reproductive cell abnormalities, pregnancy risk increases in the past 3 months, or has history of drug abuse * Any one of the couple has malignancy * The wife has uncontrolled hypertension or refractory hypertension * The wife has diabetes mellitus * The wife has albuminuria * The wife has autoimmune disease * The wife has other disorders or functional abnormalities, such as liver or renal dysfunction, which may be aggravated by pregnancy or assisted reproduction * Allergy to drugs or related products which cannot avoid in our study * Participating in other clinical studies in last 3 months * Participants cannot follow the study program * Other conditions that the researchers considered unsuitable for participation