Pregnant African American women between 18 and 45 years of age will be enrolled at 20 weeks of gestation or less. Biological specimens (vaginal swabs, rectal swab) will be collected at enrollment, 23-24 weeks, at 28-29 weeks, and at the onset of labor. A urine sample will be obtained at entry and at the time of delivery for metabolomic analysis. Participants will also collect a dietary survey at entry, 23-24 weeks, and 28-29 weeks. The biological specimens will then be analyzed for their microbiomial profile. This will then be correlated with the timing of their delivery as well as other comorbidities such as obesity, hypertension, and diabetes.
Study Type
OBSERVATIONAL
Enrollment
55
Survey is collected on the dietary intake of both cohorts. Sample collection is done from patients in both cohorts at multiple time points.
Preterm Delivery
Onset of preterm labor with subsequent spontaneous preterm birth
Time frame: 36 weeks
Microbiome profile
Evaluation of characteristics of the vaginal microbiome in cohorts
Time frame: 36 weeks
Metabolomic profile
Evaluation of characteristics of the metabolomic products present in cohort
Time frame: 36 weeks
Medical comorbidities
Evaluation of the comorbidities present in the cohort
Time frame: 36 weeks
Gut Microbiome profile
Evaluation of the characteristics of the gastrointestinal microbiome in cohorts
Time frame: 36 weeks
Term delivery
Delivery at term
Time frame: 36 weeks
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