MERIT Study - Mistral Percutaneous Mitral Valve Repair FIM Study

Inclusion Criteria: * Subject is willing and able to comply with all required follow-up evaluations * Genders eligible for the study: Both genders * Subject has functional MR of grade 3+ or more * Subject has left ventricular ejection fraction (LVEF) \>20 % and \< 40%. * No contraindications to trans-septal puncture * Subject is of functional class 3 or more (NYHA) * The subject is high risk to undergo MV surgery. * Subject is excluded from other standard of care procedures as determined by center heart team. * Patients with femoral veins enabling catheterization with 12Fr catheters * Life expectancy ≥ 1 year Exclusion Criteria: * Mitral Stenosis ≥ moderate * Aortic Stenosis/Insufficiency \> moderate * Subvalvular calcification or calcification of the chordae. * Subject has a prosthesis valve in the mitral position * Transcatheter aortic valve replacement (TAVR) within 30 days prior to subject registration * Subject has a history of a cerebral vascular accident (CVA) or transient ischemic attack (TIA) within the past 3 months. * Subject has a history of a myocardial infarction (MI) in the past 3 months * Subject refuses blood transfusion or surgical valve replacement. * Subject has had a percutaneous interventional or other invasive cardiac or peripheral procedure ≤ 7 days of the index procedure * Subject has a history of, or has active endocarditis * Subject has echocardiographic evidence of intra-cardiac mass, thrombus, vegetation or soft-mobile deposits * Subject is in acute pulmonary edema. * Subject has hemodynamic instability requiring inotropic or mechanical support. * Subject has a known hypersensitivity or contraindication to anticoagulant or antiplatelet medication * Subject has renal insufficiency as evidenced by a serum Creatinine \> 3.0mg/dL. * Subject has ongoing infection or sepsis * Subject has blood dyscrasias (leukopenia, acute anemia, thrombocytopenia, history of bleeding diathesis, or coagulopathy) * Subject has an active peptic ulcer or has had gastrointestinal (GI) bleeding within the past 3 months prior to the index procedure * Subject requires emergency surgery for any reason * Subject has a known allergy to Nitinol alloys, 316L\\304 stainless steel. * Pregnant or lactating women. * Patients being dependent upon the sponsor or upon the investigator or upon the investigational site. * Subject has a known contrast media allergy * Presence of high degree atrio-ventricular block (2nd or 3rd degree A-V block), or the presence of tri-fascicular block * According to investigator on site the patient is suffering from a severe end stage disease (e.g. malignancy, severe pulmonary disease, liver disease, renal failure) and has a life expectancy of less than 1 year.