Endoscopic Sleeve Gastroplasty

Inclusion Criteria: * Patient \> 18 years old and \< 60 years old * Patient with morbid obesity for at least 2 years * Patient who failed medical and diet treatment of obesity * Patient with no contraindication to anesthesia * Patient able to understand the study and to provide informed consent. Exclusion Criteria: * Patient with inflammatory, tumoral or bad quality tissues at endoscopy * Patient with a history of gastro-intestinal inflammatory disease, stenosis or intestinal adhesions, kidney or liver failure, chronic pancreatic disease * Patient with a history and/or signs and/or symptoms of gastroduodenal ulcerous disease and/or progressive gastroduodenal ulcerous disease * Patient with an oesophageal pathology as Zenker's diverticulum, peptic oesophagitis stage 3-4, oesophageal stenosis, Barrett syndrome, oesophageal cancer, dysphagia, achalasia * Patient with previous bariatric, gastric or oesophageal surgery, intestinal obstruction, portal hypertension, gastro-intestinal tumors, oesophageal or gastric varices, gastroparesis * Patient with a severe coagulopathy (prothrombin time \> 3 seconds or thrombocytic count \< 50 000/mm3) or treated with heparin, coumadin, warfarin or any other anticoagulants and drugs preventing coagulation or platelet aggregation, except aspirin and nonsteroidal anti-inflammatory drugs * Pregnancy, breastfeeding or woman without contraception * Patient with a congestive heart failure, arrhythmia or unstable coronary heart disease * Patient using or having used diet drugs within the last 30 days or intending to use them during study follow-up * Patient under drug treatment within the last 3 months known to induce weight gain * Patient with eating disorders or uncontrolled, poorly controlled or suspected psychiatric disease * Patient in a poor condition according to investigator * Patient in exclusion period (determined by a previous study or in progress) * Patient with significative weight loss between date of enrollment in the study and date of procedure * Patient with a systemic infection the day of procedure.