Elevated LDH Serum Levels and FDG-PET in Metastatic Melanoma Patients

University Medical Center Groningen65 enrolled

Overview

A retrospective study investigating the relationship between FDG-PET uptake and LDH levels.

Patient characteristics, tumour characteristics including the BRAF mutation status and baseline serum S100B and LDH levels of each patient will be retrospectively determined from the electronical patient file. In each patient, tumour burden and 18F-FDG uptake of the tumour lesions will be measured using multiple standard quantification parameters of the baseline 18F-FDG-PET scan. Tumour burden will also be measured on the baseline contrast enhanced CT scan. The correlation of each FDG-PET parameter with baseline LDH and S100B levels, respectively, will be analyzed using univariate and multivariate regression analysis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Melanoma

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- All patients \>18 years with histologically proven metastatic melanoma (American Joint Committee on Cancer \[AJCC\] stage IV melanoma) treated in the UMCG between May 2014 and December 2015. Exclusion Criteria: * participation in interventional studies * missing baseline 18F-FDG PET scan and/or baseline contrast enhanced CT scan * missing baseline serum LDH level * missing BRAF mutation status, concurrent malignancies or a history of previous malignancies.

Locations (1)

University Medical Center Groningen

Groningen, Netherlands

Outcomes

Primary Outcomes

Independent correlation between baseline serum LDH level and 18F-FDG uptake of tumour lesions

Time frame: 3 months

Secondary Outcomes

Correlation between baseline serum LDH level and tumour 18F-FDG uptake in subgroups separated by metastasis site

Time frame: 3 months

Correlation between baseline serum S100B level and tumour 18F-FDG uptake

Time frame: 3 months

Difference between tumour burden as measured on CT scan and on 18F-FDG-PET

Time frame: 3 months

Difference between tumour volume as determined by manual measurement or semiautomatic measurement

Time frame: 3 months

Correlation of baseline serum LDH level with tumour volume as measured on CT scan and as measured on 18F-FDG-PET scan

Time frame: 3 months

Data from ClinicalTrials.gov

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