Using a double-blind, randomized controlled design to investigate the additional therapeutic effects of 3 times of combined triamcinolone and hyaluronic acid injections to 3 times of hyaluronic acid injections to patients with knee osteoarthritis.
A total of 56 patients will be enrolled and randomized into two groups, including 3 times of triamcinolone combined hyaluronic acid injections group and 3 times of hyaluronic acid injections group. The triamcinolone combined hyaluronic acid injections group will receive 3 times of triamcinolone combined hyaluronic acid injection per week in three weeks; the hyaluronic acid group will receive hyaluronic acid injection in three weeks. Physical activities and functional performance will be evaluated at before injection, at after one week, one month, three months, and six months of completion of 3 times of injections.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
56
compare the additional therapeutic effects of triamcinolone combined with hyaluronic acid injections to hyaluronic acid injections only to patients with knee osteoarthritis
compare the additional therapeutic effects of triamcinolone combined with hyaluronic acid injections to hyaluronic acid injections only to patients with knee osteoarthritis
Shin Kong Wu Ho-Su Memorial Hospital
Taipei, Taiwan
Functional performance assessed with the Western Ontario and McMaster Universities Osteoarthritis Index
Western Ontario and McMaster Universities Osteoarthritis Index
Time frame: changes from baseline to at after one week, one month, three months, and six months of completion of injections
10 meter walk test
10 meter walk as fast as possible
Time frame: changes from baseline to at after one week, one month, three months, and six months of completion of injections
Quality of life assessed with the Knee Injury and Osteoarthritis Outcome Score
Knee Injury and Osteoarthritis Outcome Score
Time frame: changes from baseline to at after one week, one month, three months, and six months of completion of injections
5 times rapid chair rising test
rapid chair rising for 5 times as fast as possible
Time frame: changes from baseline to at after one week, one month, three months, and six months of completion of injections
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