Impact of Exercise Therapy on Functional Capacity in Patients Listed for Liver Transplantation

Matthew Armstrong18 enrolled

Overview

A UK prospective, single-centre feasibility study investigating the effects of exercise therapy on functional capacity in patients on the waiting list for liver transplantation. Patients will receive a 12-week home prehabilitation program (daily step program; functional resistance exercise sessions; telephone health call or virtual clinic). The following will be assessed at weeks 0, 6 and 12 weeks: feasibility (recruitment, compliance, safety, patients perception), functional capacity (ISWT, SPBT), psychological wellbeing (HADS questionnaire) and quality of life (EQ-5D)

as above

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Liver Cirrhosis Liver Dysfunction

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Meet the United Kingdom Liver Transplant criteria for listing * Accepted on the liver transplant waiting list for a primary transplant * Adults ≥18years who have an indication for a liver transplant * Diagnosed with sarcopenia at liver transplant assessment Exclusion Criteria: * Significant cardiovascular instability including a recent Myocardial infarction, recent Cerebrovascular accident and/or a recent unstable arrhythmia * Unstable encephalopathy - open to interpretation by the chief investigator * Patient or next of kin non-English speaking * Inpatients * Refusal or lacks capacity to give informed consent

Outcomes

Primary Outcomes

Number of participants with intervention-related adverse events as assessed by CTCAE v4.0

As this is a feasibility/Pilot study the investigators need to assess if any participants have any adverse events related to the home prehabilitation programme and if so, determine the severity and frequency

Time frame: 12-week