Mouthwash of Pomegranate Against Biofilm and Gingival Inflammation in School Children

Universidade Estadual da Paraiba35 enrolled

Overview

The mechanical control of supragingival biofilm is accepted as one of the most important measures to prevent dental caries and periodontal diseases. Nevertheless, maintaining dental surfaces biofilm-free is not an easy task. In this regard, numerous studies researches have demonstrated the effectiveness of mouthwashes containing antimicrobial active ingredients that prevent and control both supragingival biofilm and gingivitis, specially when used adjunctively to mechanical oral hygiene regimens.

In vitro and clinical researches using Punica granatum Linn shows antimicrobial and antiadherent activity against dental biofilm microorganisms. The purpose of this study was to evaluate the clinical effectiveness of a mouthwash of Punica granatum Linn. against biofilm and gingival inflammation in school children

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Gingivitis

Interventions

Punica granatum Linn.DRUG

Mouthwash (6,25% of Punica granatum Linn) 10mL per day during 14 days

chlorhexidineDRUG

standard anti-bacterial mouthwash Mouthwash (0,12% chlorhexidine) 10mL per day during 14 days

Eligibility

Sex: ALLMin age: 9 YearsMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age group: 09-12 years old * Presence of at least 20 teeth * Simplified Oral Hygiene Index (S-OHI)≥ 1,6 Exclusion Criteria: * Use of orthodontic appliance * Recent (in the past 2 months)use of antibiotics and mouthwashes

Locations (1)

Universidade Estadual Da Paraiba

Campina Grande, Paraíba, Brazil

Outcomes

Primary Outcomes

Difference in the Gingival Index scores.

On day 0, we measured the Plaque Index (PI) (Silness; Löe, 1964) at baseline, on the seventh day and on the fourteenth day.

Time frame: Baseline, Seventh Day and Fourteeth day (14 days)

Difference in the Gingival Bleeding Index scores.

On day 0, we measured the Bleeding on Probing Index (BPI) (Ainamo; Bay, 1975) at baseline, on the seventh day and on the fourteenth day.

Time frame: Baseline, Seventh Day andFourteeth day (14 days)

Difference in the Microbiological analysis of saliva for oral streptococcus count evolution from the start till the end of the study.

At baseline, we collected non-stimulated saliva samples into a sterile container for counting of oral streptococci in the laboratory. And on the fourteenth day, we carried out the second saliva collection and measured the clinical indices used.

Time frame: Baseline and Fourteeth day (14 days)

Data from ClinicalTrials.gov

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