Prospective, crossover, randomized trial to evaluate plasma compositions after loading dose of sterofundin solution given to healthy volunteer in the resuscitation manner compared with normal saline solution.
10 healthy volunteers were randomly assigned to receive either normal saline or sterofundin for the first solution in dose of 30 mL/kg (max 2 L) over 1 hour. Blood was collected at baseline (T0), at 60 minutes (T1), 120 minutes (T2), and 240 minutes (T4) from baseline. Time to fist void after initiation of fluid and urine volume were also recorded. After wash-out period of at least 1 week, crossover studies were performed with another fluid.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
20
Fluid loading
Fluid loading
Change in serum chloride
At 0, 1, 2, and 4 hours from initiation
Time frame: 4 hours
Change in serum pH
At 0, 1, 2, and 4 hours from initiation
Time frame: 4 hours
Change in serum osmolality
At 0, 1, 2, and 4 hours from initiation
Time frame: 4 hours
Change in serum SID
At 0, 1, 2, and 4 hours from initiation
Time frame: 4 hours
Time to first void
Time in minutes from initiation of fluid to first urination
Time frame: Within 24 hours
Urine volume
Volume of first urination in ml
Time frame: Within 24 hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.