The purpose of this study is to learn about health care use, costs, and clinical outcomes over time for amyloid positive participants with early stages of AD in the United States. This study is for research purposes only, and is not intended to treat any medical condition. No study therapy(ies) for AD will be administered.
Study Type
OBSERVATIONAL
Enrollment
1,400
Florbetapir F 18 positron emission tomography (PET) scan performed at baseline to confirm amyloid status. Participants who previously tested amyloid positive were exempt. No therapeutic investigational drug(s) intended to treat AD will be administered.
Mean Economic Cost Associated with Amyloid Positive AD
Time frame: Baseline through Study Completion (36 Months)
Healthcare Resource Use by AD Cohort
Time frame: Baseline through Study Completion (36 Months)
Mean Economic Cost by AD Cohort
Time frame: Baseline through 24 Months
Bath Assessment of Subjective Quality of Life in Dementia (BASQID)
Time frame: Baseline, End of Study (36 Months)
Mini-Mental State Examination (MMSE)
Time frame: Baseline, End of Study (36 Months)
Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog14)
Time frame: Baseline, End of Study (36 Months)
Neuropsychiatric Inventory (NPI)
Time frame: Baseline, End of Study (36 Months)
Functional Activities Questionnaire (FAQ)
Time frame: Baseline, End of Study (36 Months)
Cognitive Function Inventory (CFI)
Time frame: Baseline, End of Study (36 Months)
Zarit Burden Interview (ZBI)
Time frame: Baseline, End of Study (36 Months)
Percentage of Participants with a Change in Living Situation
Time frame: 36 Months
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California Pharmaceutical Research Institute
Anaheim, California, United States
Advanced Research Center
Anaheim, California, United States
Sun Valley Research Center
Imperial, California, United States
Global Clinical Trials
Irvine, California, United States
Irvine Clinical Research Center
Irvine, California, United States
Alliance Research Centers
Laguna Hills, California, United States
Pacific Clinical Studies, Inc
Los Alamitos, California, United States
California Neurological Services, Inc.
Panorama City, California, United States
Havana Research Institute
Pasadena, California, United States
Clinical Innovations, Inc.
Riverside, California, United States
...and 67 more locations
Time to Transition Across Stages of AD
Time frame: Baseline through Study Completion (36 Months)
Desire to Institutionalize Scale (DTI)
Time frame: Baseline through Study Completion (36 Months)