The Effect of Frequency and Duration of Breaks in Sitting Time on Metabolic Cardiovascular Risk Factors

Rigshospitalet, Denmark14 enrolled

Overview

The primary aim of this study is to investigate the acute effect of the frequency and duration of breaks in sitting time on the metabolic risk factor profile.

Fifteen (n=15) sedentary adult overweight males will be included in the study. All participants will undergo the four interventions in a randomized cross-over design. Wash out between intervention will be minimum four days. Control (CON): Participants will be sedentary. Sedentary time will be spent sitting in a chair, restricted to sedentary behaviors (working on a computer, reading, watching TV, etc.), with a target MET below 1.5 (i.e. 1.5 times REE). Participants will only be allowed to stand or walk to go to the toilet. Breaker: Participants will be breaking up prolonged sitting with 2 min intervals of low intensity walking. Intermediate: Participants will be breaking up prolonged sitting with 6 min intervals of low intensity walking Prolonger: Participants will be breaking up prolonged sitting with 12 min intervals of low intensity walking All interventions will be matched for total physical activity as well as sitting. Thus, we aim for the active interventions to be iso-caloric.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Sedentary Lifestyle Overweight and Obesity Metabolic Disease

Interventions

ControlBEHAVIORAL

Control intervention

BreakerBEHAVIORAL

Short breaks of physical activity

ProlongerBEHAVIORAL

longer breaks of physical activity

Intermediate

Eligibility

Sex: MALEMin age: 20 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Males, age 20-50 years, waist-to-height ratio ≥ 0.5 and/or waist circumference ≥ 102 cm. Exclusion Criteria: * Clinically diagnosed diabetes, uncontrolled hypertension, use of glucose- and/or lipid-lowering medication, smoking, evidence of thyroid, liver, lung, heart or kidney disease, non-sedentary occupation, and VO2max levels above the considered average fitness according to age (Shvartz \& Reibold 1990), contraindications to increased levels of physical activity.

Locations (1)

Center for Physical Activity Research, Copenhagen University Hospital

Copenhagen, Denmark

Outcomes

Primary Outcomes

AUC post prandial glucose concentration

Time frame: 6 hours

Secondary Outcomes

AUC post prandial insulin concentration

Time frame: 6 hours

AUC post prandial c-peptide concentration

Time frame: 6 hours

AUC post prandial triglyceride concentration

Time frame: 6 hours

AUC post prandial total cholesterol concentration

Time frame: 6 hours

AUC post prandial ldl concentration

Time frame: 6 hours

AUC post prandial hdl concentration

Time frame: 6 hours

AUC post prandial glucagon concentration

Time frame: 6 hours

Mean 24 hour glucose concentration

Time frame: 24 hours

Variation in 24 hour glucose concentration

Time frame: 24 hours

Maximum in 24 hour glucose concentration

Time frame: 24 hours

Data from ClinicalTrials.gov

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