Abuse and Addiction in ICU

Seoul National University Hospital200 enrolled

Overview

Investigators are seeking to determine the impact of recent alcohol, smoking or psychotropic drug use prior to intensive care unit (ICU) admission on incidence of delirium and sedation requirements. Study design: A prospective observational study, in a medical ICU of a tertiary university hospital. Methods: For all new ICU admissions, a 1-page questionnaire including Alcohol Use Disorders Identification Test (AUDIT-C), smoking history and prior medication use was given to the patient or closest family members. Delirium was assessed by trained ICU nurses using Intensive Care Delirium Screening Checklist and Richmond Agitation-Sedation Scale.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Substance Withdrawal Syndrome

Interventions

AUDIT-COTHER

Patients or their proxy/closest family member(s) undergo a comprehensive questionnaire including AUDIT-C about his/her alcohol behavior during last year and will be categorized into two groups: Those with AUDIT-C\>4 versus AUDIT-C of 4 or below.

Smoking historyOTHER

Patients or their proxy/closest family member(s) undergo a comprehensive questionnaire including smoking history during last year and will be categorized into two groups: Current smoker versus ex- or never smoker (we also recorded smoking pack-years to distinguish heavy smokers)

Prior psychotropic medication useOTHER

Patients or their proxy/closest family member(s) undergo a comprehensive questionnaire including psychotropic medication use prior admission to ICU and will be categorized into two groups: Those who use psychotropic medication versus those who do not use psychotropic medication.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who are older than 18 years of age * New patients admitted to medical ICU for the 1st time during their stay in hospital Exclusion Criteria: * Had history of stroke or other primary neurologic disease * GCS ≤ 8 prior to ICU admission * Transferred from other ICU (except for emergency ICU stay which is limited to less than 36 hours) * Not registered within 24 hours after admission * Refused to participate * If comatous state persists * Delirium assessment is not possible due to newly developed neurologic disease, such as cerebral infarction * Medical ICU stay less than 24 hours * Readmission to medical ICU

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Delirium during ICU stay

Time frame: From date of ICU admission until the date of ICU discharge, whichever came first, assessed up to 3 months

Secondary Outcomes

ICU length of stay

Time frame: From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months

Mortality

Death in MICU

Time frame: From date of ICU admission until the date of death, assessed up to 3 months

Maximal doses of dexmedetomidine

Time frame: From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months

Cumulative dose of dexmedetomidine

Cumulative dose of dexmedetomidine during the patient's MICU stay

Time frame: From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months

Cumulative dose of midazolam

Cumulative dose of midazolam during the patient's MICU stay

Time frame: From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.