Ovarian Tumor Biopsies to Study Response to Treatments

University Health Network, Toronto5 enrolled

Overview

This is a research study to look at differences in tumor tissue from ovarian cancer patients that may help to determine response and resistance to treatments.

Ovarian cancer participants will be asked to have two tumor biopsies during the research study. The first biopsy will be done prior to receiving the participants' assigned treatments as a part of their cancer care and the second biopsy will be done about 3-7 days after starting treatment. Participants who will undergo neoadjuvant treatment and then surgery, will also have their tumor tissue collected during surgery. Participants whose disease worsens while on treatment will also be asked to have an additional, optional tumor biopsy. The tumor tissue samples will be studied to look at certain proteins and enzymes, including enzymes called kinomes, that may be important in determining response and resistance to the treatment that participants will receive as a part of their cancer care.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Epithelial Ovarian Cancer

Interventions

Blood DrawPROCEDURE

CA125 and ctDNA

Tumor Tissue BiopsyPROCEDURE

Only collected at time of surgery if patient undergoes surgical debulking

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥18 years. * Histological diagnosis of epithelial ovarian cancer * Eastern Cooperative Oncology Group (ECOG) performance status ≤2. * Life expectancy of greater than 3 months * Diagnosis of epithelial ovarian cancer undergoing chemotherapy as part of standard care or a clinical trial OR receiving a targeted therapy with a targeted agent * Must be agreeable to paired biopsies * Must have disease amenable to paired biopsy. * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Any contraindication to biopsy * Need for anticoagulation that cannot be interrupted

Locations (1)

Princess Margaret Cancer Centre

Toronto, Ontario, Canada

Outcomes

Primary Outcomes

Pearson correlation for changes between kinome and CA125

Time frame: 5 years

Paired T-test for differences in kinome between responders and non-responders

Time frame: 5 years

Data from ClinicalTrials.gov

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