The effects and safety of Human cord blood mononuclear cell for delayed encephalopathy after carbon monoxide poisoning
To evaluate the effect and mechanism of human cord blood mononuclear cell transplantation for delayed encephalopathy after carbon monoxide poisoning
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
The patients were treated by human cord blood mononuclear cell through subarachnoid space
The patients were treated by hyperbaric oxygen
Liaocheng city people's hospital
Liaocheng, Shandong, China
RECRUITINGChange From Baseline in Mini-Mental State Examination (MMSE)
Time frame: Baseline, 4, 8, 12 and 24 weeks
Chang from baseline in head CT
Time frame: Baseline, 6 and 12 months
Cerebrospinal levels of IL-2,IL-4,IL-6,IL-10,TNF,IFN-γ，IL-17A，IL-8，IL-12p70，MIG，MCP-1(ng/ul)
Time frame: Baseline, 1 and 2 months
Serum levels of IL-2,IL-4,IL-6,IL-10,TNF,IFN-γ，IL-17A，IL-8，IL-12p70，MIG，MCP-1(ng/ul)
Time frame: Baseline,1 and 2 months
Change From Baseline in Activities of Daily Living (ADL)
Time frame: Baseline, 4, 8, 12 and 24 weeks
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