This double-blind, randomized controlled trial will evaluate the effect of the route of administration of 10 IU of oxytocin on the average blood loss postpartum. Participants will be randomized to receive 10 IU of oxytocin by IV infusion or 10 IU of oxytocin by injection IM
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
543
Hospital J.R. Vidal
Corrientes, Argentina
Amount of blood loss (mL)
Time frame: 1 hour postpartum
Proportion of women who had postpartum blood loss ≥500 ml
Time frame: 1 hour postpartum
Proportion of women who had postpartum blood loss ≥1000 ml
Time frame: 1 hour postpartum
Average change in hemoglobin level
Time frame: pre-delivery and at least 24 hours postpartum
Average time required until expulsion of the placenta
Time frame: 1 hour postpartum
Proportion who needed additional Interventions
Time frame: Through study completion, an average of 24-48 hours postpartum
Side effects
Time frame: 1 hour postpartum
Blood pressure
Time frame: 15, 30, 45 and 60 minutes postpartum
Heart rate
Time frame: 15, 30, 45 and 60 minutes postpartum
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