MICRO-RNAs OF NEUTROPHILS IN RENAL ANTINEUTROPHIL CYTOPLASMIS ANTIBODY (ANCA) -ASSOCIATED VASCULITIS

Nantes University Hospital63 enrolled

Overview

Activation of neutrophils by ANCA ("Anti-Neutrophil Cytoplasm Antibodies") and subsequent microvascular endothelial cell damage is the main feature of ANCA-associated vasculitis (AAV), a severe autoimmune disease that often targets the kidney. There is no specific treatment for AAV to date and 25% of patients with renal damage evolve towards end-stage renal disease, requiring dialysis and kidney transplantation. In addition, there is no reliable biological marker of the disease activity available, which makes the diagnostic, follow-up and treatment of patients difficult. Therefore, the identification of new therapeutic targets and non-invasive biomarkers constitutes a major clinical challenge to improve AAV patients care and to ameliorate their renal outcome.

Study Type

OBSERVATIONAL

Enrollment

Conditions

ANCA-associated Vasculitis

Interventions

Non interventional studyOTHER

This is a non interventional study because all levies are performed during visit planned for the care of patients.

Medical Language ↔ Plain English

Inclusion Criteria for patients: * Adult patients aged over 18 years * Patients with Granulomatosis with polyangiitis or microscopic polyangiitis meeting the criteria of Chapel Hill. * corticosteroid treatment \<20 mg / day. * Informed consent: oral for participation in research and writing for biological collection. Inclusion Criteria for controls patients: \- healthy-topics matched for age, recruited from the Etablissement français du sang or in the Department of Internal Medicine of Nantes University Hospital Non Inclusion Criteria: * ANCA-associated vasculitis with Eosinophilic granulomatosis with polyangiitis (AAV-EGPA). * Infectious or progressive tumor pathology. * Pregnancy, lactation * Treatment with cyclophosphamide in the 6 months prior to inclusion. * Terminal chronic renal failure, presence of organ allograft. * Thrust Patients receiving corticosteroids\> 20 mg / d in the previous 4 weeks. * Inability to give informed about information (subject in emergencies, understanding of the subject of difficulty, ...) * Minor subject, under judicial protection, guardianship

MICRO-RNAs OF NEUTROPHILS IN RENAL ANTINEUTROPHIL CYTOPLASMIS ANTIBODY (ANCA) -ASSOCIATED VASCULITIS

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes