Clinical Trial to Assess the Pharmacokinetic Characteristics of Lodivikar Tab. 5/40 mg in Healthy Adult Male Subjects

Inclusion Criteria: * Healthy male in the age of 20-45 * Body weight ≥ 55kg, IBW ± 20% * Subject who sign on an informed consent form willingly Exclusion Criteria: * Subject with serious active cardiovascular, respiratory, hepatologic, renal, hematologic, gastrointestinal, immunologic, dermal, neurologic, or psychological disease or history of such disease * Subject with known for hypersensitivity reaction to S-amlodipine, amlodipine and olmesartan and dihydropyridine derivatives * Clinically significant hypotension (SBP≤100mmHg, DBP≤60mmHg) or hypertension(SBP≥150mmHg, DBP≥95mmHg) when screening period * Subject with known for history of disease or gastric surgery which affect on the absorption, * Subject with any of the following conditions in laboratory test * AST or ALT \> UNL (upper normal limit) x 1.5 * Total bilirubin \> UNL x 1.5 * Renal failure with CLcr \< 50mL/min calculated on Cockcroft-Gault \[Cockcroft-Gault GFR = (140-age) \* (Wt in kg) / (72 \*Cr)\] * Serum potassium \< 3.5 mEq/L or \> 5.5 mEq/L * Continued excessive use of caffeine (caffeine \>five cups/day), alcohol(alcohol\>30g/day) and severe heavy smoker(cigarette \>10 cigarettes per day) * Participation in any clinical investigation within 60days prior to study medication dosing * Subject with whole blood donation within 60days, component blood donation within 30days prior to study medication dosing * Subject taking inducer or inhibitor of drug metabolism enzyme such as barbital within 28days prior to study medication dosing * Use of any prescription medication including oriental medication within 14 days prior to study medication dosing or over-the-counter medication within 7 days prior to study medication dosing * Subject with mental illness or drug addiction * Subject taking foods which affect on the absorption, distribution, metabolism or excretion of drug within 7days prior to study medication dosing * Subject with decision of nonparticipation through investigator's review due to laboratory test results or other excuse such as non-responding to request or instruction by investigator