The purpose of this study is to provide continued supply of ruxolitinib alone, ruxolitinib plus background cancer therapy, or background cancer therapy alone to subjects from an Incyte-sponsored study of ruxolitinib that has reached its study objectives or has been terminated. This study will also provide another mechanism for reporting adverse events related to study drug safety.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
10
5 mg BID
Capecitabine at the same dose provided in the parent study at the time of the rollover.
Regorafenib at the same dose provided in the parent study at the time of the rollover.
UCLA Healthcare Hematology-Oncology
Santa Monica, California, United States
University of Louisville
Louisville, Kentucky, United States
New York Oncology Hematology Pc.
Clifton Park, New York, United States
Tennessee Oncology
Nashville, Tennessee, United States
University of Texas M. D. Anderson Cancer Center
Houston, Texas, United States
Renovatio Clinical Consultants Llc
The Woodlands, Texas, United States
Sp Zoz Szpital Uniwersytecki W Krakowie Oddzial Kliniczny Hematologii
Krakow, Poland
Samodzielny Publiczny Szpital Kliniczny
Lublin, Poland
Instytut Hematologii I Transfuzjologii
Warsaw, Poland
Frequency and types of adverse events and serious adverse events
Subjects will be treated until disease progression or discontinuation criteria are met.
Time frame: Maximum duration of every 2 months (maximum duration of 1 month for subjects receiving regorafenib) from enrollment through 30-37 days after end of treatment up to 24 months.
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