The Effects of BCRP Q141K on Allopurinol Pharmacokinetics and Dynamics

Inclusion Criteria: * self-identified as Asian/European ancestry * generally healthy with approved lab values for CBC,HFP,RFP, and uric acid * Subjects with the ABCG2 genotype, homozygous, heterozygous or homozygous for the major allele of rs2231142 will be recruited Exclusion Criteria: * vascular disease * renal impairment * medications/supplements that affect uric acid levels * pregnant or lactating women * prior history of allergic reaction to allopurinol or testing positive for HLA-B\*5801 allele * risk of urinary or gastric retention or narrow-angle glaucoma * impaired hepatic function * evidence of anemia * evidence or diagnosis of congestive heart failure * smokers * subjects with a mutation other than rs2231142 in the ABCG2 genotype * subjects taking hormonal contraceptives or other hormonal medications * evidence of recreational drug use as determined by questionnaire