SATIOSTAT is a composition comprising a specific dietary fibre component (a mixture of hydrocolloids with excellent safety profiles and a long history of use in humans) and a lipid component (long-chain fatty acids). The goal of this combination is to achieve long-acting delivery of long-chain fatty acids to the intestinal lining, triggering the sustained release of satiety-signals from intestinal cells, and consequently reducing appetite and lowering food intake in humans. Effects of acute ingestion of SATIOSTAT vs. a control will be examined. On a first and second study day, volunteers receive a preload of either SATIOSTAT or a control and then an oral glucose load of 75g enriched with C13 sodium acetate. Gastric emptying will be measured by means of a breath test, and insulin, glucose and satiation hormones will be assessed. On the third and fourth study day, volunteers receive a preload of either SATIOSTAT or a control and are then presented a test meal. Total calorie intake is measured as well as subjective feelings of satiation. In addition satiation hormones are measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
15
Control granulates (maize starch and long-chain fatty acids) with powder; 75g oral glucose load
SATIOSTAT granulates (hydrocolloids (fibers) and long-chain fatty acids) with powder; 75g oral glucose load
Control granulates (maize starch and long-chain fatty acids) with powder; test meal (ham sandwiches: 50g bread, 10g butter, 29g ham (pork); 247 kcal/sandwich) and tap water)
SATIOSTAT granulates (hydrocolloids (fibers) and long-chain fatty acids) with powder; test meal (ham sandwiches: 50g bread, 10g butter, 29g ham (pork); 247 kcal/sandwich) and tap water)
St Claraspital
Basel, Switzerland
Acute effects of SATIOSTAT on gastrointestinal (GI) peptide release measured by ELISA
measured by commercially available ELISA (enzyme-linked immunosorbent assay )-kits
Time frame: changes from baseline to three hours after treatment
Acute effects of SATIOSTAT on glucose tolerance measured by oral glucose tolerance test
measured with oral glucose tolerance test
Time frame: changes from baseline to three hours after treatment
Acute effects of SATIOSTAT on gastric emptying measured by 13C-sodium-acetate breath test
measured by 13C-sodium-acetate breath test
Time frame: changes from baseline to four hours after treatment
Acute effects of SATIOSTAT on subjective feelings of hunger and satiety measured by visual analogue scales
measured by visual analogue scales
Time frame: changes from baseline to three hours after treatment
Acute effects of SATIOSTAT on subsequent calorie intake measured by calorie intake from a test meal
calorie intake from a test meal will be assessed
Time frame: changes from baseline to two hours after treatment
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