Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine Treatment

Shanghai First Maternity and Infant Hospital144 enrolled

Overview

Based on multi-center clinical research resources, a large-scale prospective cohort study will be conduted to make a more accurate diagnosis and intervention plan of Non-immune fetal hydrops (NIFH), and then establish NIFH accurate treatment strategy which is suitable for China's national conditions.

1. Etiological study of Non-immune fetal hydrops(NIFH): 1. Etiological study of NIFH in mid-pregnancy period; 2. Etiological study of NIFH and hygroma colli in first trimester; 3. Value assessment of technology for exome sequencing in diagnosis of NIFH; 2. The accuracy of NIFH intrauterine intervention and its effect assessment: 1. Perinatal outcomes of NIFH ; 2. The effect of intrauterine treatments.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

144

Conditions

Fetal Hydrops

Interventions

intrauterine interventionPROCEDURE

choose different surgeries according to different causes

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cases corresponding to diagnosis standards * Willing to accept the regular follow-up Exclusion Criteria: * Immune hydrops fetalis * Multiple pregnancy, except for twin-to-twin transfusion syndrome IV

Outcomes

Primary Outcomes

Neonatal mortality

Time frame: 1 year

Secondary Outcomes

Success rate for the operation

Time frame: 1 week

Data from ClinicalTrials.gov

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