The purpose of this study is to develop an immune-phenotype based prediction of postoperative SIRS in patients undergoing open heart surgery.
The study will have a pre-, intra and postoperative phase in which several demographic and clinical variables will be assessed. The samples for the immunophenotypic analysis will be drawn directly after induction of anesthesia and at various time points after end of surgery. The diagnosis of SIRS will be made during routine clinical visits on the first seven postoperative days using the Sepsis-related Organ Failure Assessment score (SOFA-score). The patients will be followed up for 30 days.
Study Type
OBSERVATIONAL
Enrollment
50
Multiplex assays for screening pro- and anti-inflammatory markers and RNA will be analysed using a next generation sequencing approach
University Hospital Bonn
Bonn, Germany
RECRUITINGNumber of participants with SIRS as assessed by SOFA-Score
The study investigates the relationship between the intra-individual inflammatory patterns in patients with uncomplicated (no SIRS) and complicated postoperative courses (SIRS) after open heart surgery. The diagnosis of SIRS will be made by using the Sepsis-related Organ Failure Assessment score (SOFA-score). Patients with an increase in SOFA-score \>3 are considered to have SIRS.
Time frame: 30 days
Number of participants with need for renal replacement therapy because of acute kidney failure (AKIN classification)
Time frame: 30 days
Number of participants with infection as assessed by microbiological, serological and radiological examination
Time frame: 30 days
Number of participants with postoperative delir as assessed by CAM-ICU
Time frame: 30 days
Number of participants with myocardial injury as assessed by troponine and CK-MB serum levels
Time frame: 30 days
Number of participants with new atrial fibrillation as assessed by ECG
Time frame: 30 days
Length of stay in ICU
Time frame: 30 days
Length of stay in hospital
Time frame: 30 days
In-hospital mortality
Time frame: 30 days
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