Prospective Clinical Investigation Comparing Standard Wound Closure Technique With Drains (Control) to Standard Wound Closure Techniques With TissuGlu® and No Drains (Test) in Mastectomy

Inclusion Criteria: 1. ≥ 18 years of age; 2. Provide signed and dated informed consent form; 3. Willing to comply with all study procedures, schedules and be available for the follow-up evaluations for the duration of the study; 4. Willing to follow instructions for incision care and follow guidelines related to resumption of daily activities; 5. Agree not to schedule any additional elective surgical procedures that involve an incision until their participation in this study is complete; 6. In good general health in the opinion of the Investigator with no conditions that would significantly impact wound healing as determined by medical history, and review of recent concomitant medications; 7. Requiring a mastectomy (standard, modified, modified radical) with or without sentinel node biopsy; 8. ≤ ASA 3 - American Society of Anesthesiologists Physical Classification System Exclusion Criteria: 1. Pregnancy or lactation; 2. Known medical condition that results in compromised blood supply to tissues; 3. Known or suspected allergy or sensitivity to any test materials or reagents; 4. Any condition known to affect wound healing, such as collagen vascular disease; 5. Receiving antibiotic therapy for pre-existing condition or infection; 6. Planned immediate breast reconstruction; 7. Concurrent use of fibrin sealants or other internal wound care devices; 8. Unable to understand questions, instructions or the informed consent presentation in the language of the investigators performing the study; 9. Requiring a mastectomy with ALND (as determined at time of surgery); 10. Be participating in any conflicting medical device clinical trial within 30 days of enrollment in this study.