Disturbance of the Intestinal Microbiota by Temocillin vs Cefotaxime in Treatment of Febrile Urinary Tract Infections

Inclusion Criteria: * Males and females ≥ 18 years of age with suspected or confirmed febrile UTI, fulfilling at least one of the following signs and symptoms: * Flank pain or suprapubic pain, Tenderness over the kidney on physical examination, Urinary symptoms such as dysuria, urinary frequency or urinary urgency * Fever ≥ 38.0°C (highest temperature recorded at home or at the hospital) * Positive urinalysis tests (U-Nitrit and/or U-LPK) * Have a pre-treatment baseline urinary culture obtained * Require iv antibacterial treatment of the presumed infection * Fertile women: Agree to practice highly effective anti-contraceptive methods from study-start to TOC * Signed informed consent Exclusion Criteria: * Have a documented history of hypersensitivity or allergic reaction to any beta-lactam * Pregnant or nursing women * Receipt of any prior potentially therapeutic antibacterial agent within 1 month before randomisation and sampling for urine and faecal cultures. Exceptions will prior treatment with pivmecillinam or nitrofurantoin. * Known chronic renal insufficiency (creatinine clearance \< 10 mL/min at screening as estimated by Cockcroft-Gault), or receiving intermittent haemodialysis or peritoneal dialysis * Known colonization with ESBL * Any condition or circumstance that, in the opinion of the investigator, would compromise the safety of the subject or the quality of study data.