A Clinical Study Comparing Standard Anastomosis Closure Technique to Standard Closure Technique Plus Sylys® Surgical Sealant

Inclusion Criteria: * Be at least 22 years of age * Be scheduled for a stapled colorectal or ileorectal anastomosis procedure with or without diverting stoma * Agree to return for all follow-up evaluations and procedures specified in the protocol * Understand and give informed consent Exclusion Criteria: * Albumin \< 3 * ASA ≥ 4 * Neutropenia ≤ 800 * Pregnancy * The following conditions involving compromised immune system: AIDS (HIV positive not excluded), neutropenia * Known blood clotting disorder requiring treatment * Any condition known to effect wound healing, such as collagen vascular disease * Have known or suspected allergy or sensitivity to any test materials or reagents * Concurrent use of fibrin sealants or other anastomosis care devices * Surgery for emergency abdominal indications * Has undergone a colorectal anastomosis procedure in the previous two months * Has an emergent infection related to a previous colorectal anastomosis procedure * Is scheduled to undergo a Hartmann's procedure * Is scheduled to undergo trans-anal endoscopic microsurgery (TEM) Is participating in another medical device trial related to colorectal anastomosis