"Stop Early Age-related Macular Degeneration (AMD) From Vision Loss Eternally" Study

Seoul National University Bundang Hospital21 enrolled

Overview

This study aims to validate the efficacy and safety of subthreshold laser photocoagulation on high-risk macular drusen in early age-related macular degeneration which has a high risk of conversion to exudative AMD.

SAVE Study (Stop Early Age-related Macular Degeneration form Vision Loss Eternally)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Interventions

Subthreshold Laser PhotocoagulationPROCEDURE

Selective Subthreshold Laser Photocoagulation is applied to the periphery of high-risk macular drusen

intravitreal Anti-VEGF injectionDRUG

To prevent choroidal neovascularization, intravitreal Anti-VEGF injection is done on a 3 month interval up to 1 year.

Subthreshold LaserDEVICE

Eligibility

Sex: ALLMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Drusen in both eyes examined under fundoscopy * At least one of the eyes must have high-risk soft drusen * BCVA below ETDRS 83 letters * Patient with consent to participate Exclusion Criteria: * Prior diagnosis with choroidal neovascularization * Exudative AMD in at least one eye * If the patient has only one visually effective eye (last eye) * Other macula or retinal diseases than age-related macular degeneration

Locations (1)

Seoul National University Bundang Hospital

Seongnam, Gyunggi-do, South Korea

Outcomes

Primary Outcomes

Change in drusen size

Time frame: 3 month interval

Secondary Outcomes

Best Corrected Visual Acuity (BCVA)

ETDRS and Snellen visual acuity measurement

Time frame: 3 months interval

Change in drusen distribution

Time frame: 3 month interval

Change in autofluorescence

Time frame: 3 month interval

Choroidal Neovascularization

Time frame: 3 months interval

Contrast Sensitivity

Contrast Sensitivity Test

Time frame: 3 months interval

Data from ClinicalTrials.gov

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