Efficacy of Treatment With Berberine to Maintain Remission in Ulcerative Colitis

Inclusion Criteria: 1. Diagnosis with ulcerative colitis(according to the second European evidence-based consensus on the diagnosis and management of ulcerative colitis); 2. Disease remission of ulcerative colitis(a total Mayo Clinic score of 2 points or less and an endoscopic score of 1 point or less); 3. Diagnosis of moderate or severe ulcerative colitis within 3 months(a total Mayo Clinic score of 6-12 points) Exclusion Criteria: 1. Prior bowel resection surgery; 2. Women who are planning or actual pregnancy or lactation during study period; 3. Patients allergic to berberine; 4. History of disease that would interfere with their participation in the trial, including malignant diseases, bleeding disorders, active gastric or active duodenal ulcers, autoimmune diseases, and mental or emotional disorder; 5. Take the following treatment: * Unstable dose of 5-ASA drugs (oral and/or rectal route) within 14 days prior to screening; * Unstable dose of any immunomodulating/suppressive agents and any Anti-TNF therapy within 3 months prior to screening; * Traditional Chinese Medicine for the treatment of UC (any pharmaceutical form) within 7 days prior to screening.