Is the Human Microbiome Altered in Patients With Axial Spondyloarthritis?

Eyal Kedar50 enrolled

Overview

This study aims to compare biological communities in stool samples obtained from age, diet and BMI-matched subjects in five study groups: subjects with ankylosing spondylitis (AS) never treated with tumor necrosing factor (TNF) inhibitors, subjects with ankylosing spondylitis previously or currently treated with TNF inhibitors, subjects with non-radiographic axial spondyloarthritis (nrSpA) never treated with tumor necrosing factor (TNF) inhibitors, subjects with non-radiographic axial spondyloarthritis previously or currently treated with TNF inhibitors and healthy participants. The differences in fecal microbiota composition will be explored using shotgun metagenomic sequencing through the University of Washington. The investigators predict that this study will confirm a significant difference between the fecal microbiota composition (FMC) of both AS and nrSpA patients and controls.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Axial Spondyloarthritis Ankylosing Spondylitis

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Able to provide informed consent * Male or Female patients ≥18 years of age * Additional Inclusion Criteria based on cohort Exclusion Criteria: * Current use of any pain-relieving medications other than NSAIDs, APAP and/or opioids * Corticosteroid therapy or probiotic exposure within the last two weeks * Antibiotic exposure within the past two months * History of psoriasis or inflammatory bowel disease or reactive arthritis or any other chronic rheumatologic disease * Active infection * History of hepatitis B or C or HIV * Active cancer or history of colon cancer or any form of chemotherapy or radiation within the past year * Celiac disease * Use of proton pump inhibitors within the prior two months * History of clostridium difficile * Pregnancy * Active diarrhea (defined as a decrease in fecal consistency lasting four or more weeks) * Additional Exclusion Criteria based on cohort

Is the Human Microbiome Altered in Patients With Axial Spondyloarthritis?

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes